Perry County is located far southwestern Indiana along the Ohio River. The county seat and largest town is Tell City. Perry is the hilliest county as well as one of the most forested counties in Indiana as it features more than 60,000 acres of Hoosier National Forest. The Ohio River Scenic Byway along Indiana State Road 66 runs along the southern border of the county while Interstate 64 traverses the northern portion of the county. Five volunteer fire department protect the county's 19,102 residents (2018) and 386 square miles.